Sotos syndrome (cerebral gigantism): analysis of 8 cases.

Sotos' syndrome (cerebral gigantism) with peripheral dysostosis.

Evans, P. R. (1971). Archives of Disease in Childhood, 46, 199. Sotos' syndrome (cerebral gigantism) with peripheral dysostosis. A girl had short stumpy hands and feet due to osseous dystrophy; in other respects she showed all the main and many of the minor features of Sotos' syndrome during infancy. Then she was on the 97th centile for height, but she grew to be a woman on the 10th centile. Me...

Evidence for autosomal recessive inheritance in cerebral gigantism.

Three cases of cerebral gigantism, two sibs and their double first cousin, are describedina largeinbred family from Israel. Two of the three were observed and diagnosed at birth and two were followed for two years. They all presented the signs and symptoms considered typical ofthis syndrome, as well as some ofthe less frequent findings. Generalized oedema and flexion contractures of the feet we...

Neuroblastoma in a patient with Sotos' syndrome.

Sotos' syndrome, or cerebral gigantism, is a disorder of growth regulation. Tumours have occasionally been reported in children with Sotos' syndrome, but it is uncertain whether this is a coincidence, or whether it is aetiologically related to the underlying disorder of growth. We report a 15 month old child with a paraspinal neuroblastoma and Sotos' syndrome and suggest that children with this...

Autonomic failure with persistent fever in cerebral gigantism.

Etiologies and clinical presentation of gigantism in Algeria.

BACKGROUND/AIMS True gigantism is an exceptional and fascinating pediatric disease. Our aim in this study was to describe the different etiologies of a large group of children with gigantism and the natural history of their growth. METHODS In this multicenter study, we considered as giant children, adolescents and adults whose heights were ≥3 SD compared to their target stature or to our popu...